PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2110451-0 1990 Guanine nucleotide binding properties of rap1 purified from human neutrophils. Guanine Nucleotides 0-18 RAP1A, member of RAS oncogene family Homo sapiens 41-45 2110451-1 1990 The guanine nucleotide binding properties of rap1 protein purified from human neutrophils were examined using both the protein kinase A-phosphorylated and the non-phosphorylated forms of the protein. Guanine Nucleotides 4-22 RAP1A, member of RAS oncogene family Homo sapiens 45-49 2110451-3 1990 The binding of guanine nucleotides was found to correlate with the loss of endogenous nucleotide from the rap1 protein, which was rapid in the absence of Mg2+. Guanine Nucleotides 15-34 RAP1A, member of RAS oncogene family Homo sapiens 106-110 2110451-3 1990 The binding of guanine nucleotides was found to correlate with the loss of endogenous nucleotide from the rap1 protein, which was rapid in the absence of Mg2+. magnesium ion 154-158 RAP1A, member of RAS oncogene family Homo sapiens 106-110 2110451-4 1990 The relative affinities of GTP and GDP for the binding site on rap1 were modulated by the presence of Mg2+, with a preferential affinity (approx. Guanosine Triphosphate 27-30 RAP1A, member of RAS oncogene family Homo sapiens 63-67 2110451-4 1990 The relative affinities of GTP and GDP for the binding site on rap1 were modulated by the presence of Mg2+, with a preferential affinity (approx. Guanosine Diphosphate 35-38 RAP1A, member of RAS oncogene family Homo sapiens 63-67 2110451-4 1990 The relative affinities of GTP and GDP for the binding site on rap1 were modulated by the presence of Mg2+, with a preferential affinity (approx. magnesium ion 102-106 RAP1A, member of RAS oncogene family Homo sapiens 63-67 2110451-6 1990 The dissociation of GDP from rap1 was not affected by the G-protein beta/gamma-subunit complex. Guanosine Diphosphate 20-23 RAP1A, member of RAS oncogene family Homo sapiens 29-33 2110451-8 1990 Furthermore, the ability of a cytosolic rap1 GTPase-activating protein to stimulate neutrophil rap1 GTP hydrolysis was not modified by phosphorylation. Guanosine Triphosphate 45-48 RAP1A, member of RAS oncogene family Homo sapiens 40-44 2110451-8 1990 Furthermore, the ability of a cytosolic rap1 GTPase-activating protein to stimulate neutrophil rap1 GTP hydrolysis was not modified by phosphorylation. Guanosine Triphosphate 45-48 RAP1A, member of RAS oncogene family Homo sapiens 95-99 2110451-9 1990 These data suggest that the activation of rap in vivo may be regulated by the release of endogenous GDP, but that phosphorylation by protein kinase A does not affect guanine nucleotide binding or hydrolysis. Guanosine Diphosphate 100-103 LDL receptor related protein associated protein 1 Homo sapiens 42-45