PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21055451-7 2011 Additionally, to further characterize the animals by their biochemical response to a challenge, the neurochemical changes induced by the anxiogenic compound yohimbine were measured in the medial prefrontal cortex (mPFC) of NPY-Y2 KO and compared to WT mice. Yohimbine 157-166 neuropeptide Y Mus musculus 223-226 21055451-8 2011 Dopamine (DA) levels were significantly increased by yohimbine in the WT but unaffected in the KO mice, suggesting that NPY-Y2 receptor exerts a direct control over both the tonic and phasic release of DA and that, although the anxiety-like behavior of these NPY-Y2 KO mice is unaltered, there are clear modifications of DA dynamics. Yohimbine 53-62 neuropeptide Y Mus musculus 120-123