PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20616057-4 2010 Our studies establish that a unique dual mTORC2/mTORC1 inhibitor, OSI-027, induces potent suppressive effects on primitive leukemic progenitors from CML patients and generates antileukemic responses in cells expressing the T315I-BCR-ABL mutation, which is refractory to all BCR-ABL kinase inhibitors currently in clinical use. OSI 027 66-73 CREB regulated transcription coactivator 1 Mus musculus 48-54