PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20442823-1 2009 OBJECTIVE: To study the mechanism involved in hydrogen peroxide (H(2)O(2)) or tert-butyl hydroperoxide (t-BHP)-induced potentiation of the Ang II-mediated contraction of isolated rat thoracic aorta. tert-Butylhydroperoxide 78-102 angiogenin Rattus norvegicus 139-142 20442823-1 2009 OBJECTIVE: To study the mechanism involved in hydrogen peroxide (H(2)O(2)) or tert-butyl hydroperoxide (t-BHP)-induced potentiation of the Ang II-mediated contraction of isolated rat thoracic aorta. tert-Butylhydroperoxide 104-109 angiogenin Rattus norvegicus 139-142 20442823-3 2009 To explore the probable mechanism of H(2)O(2) and t-BHP-induced potentiation of Ang II-mediated contractile response, different blockers such as losartan (AT(1) receptor blocker; 1 muM), catalase (H(2)O(2) scavenger; 500 U/ml), lercanidipine (L-type calcium channel blocker; 1 muM), geinistein (tyrosine kinase inhibitor; 100 muM), and indomethacin (cyclo-oxygenase inhibitor; 10 muM) were used. tert-Butylhydroperoxide 50-55 angiogenin Rattus norvegicus 80-83 20442823-11 2009 CONCLUSION: From the above-mentioned results, we can reasonably conclude that H(2)O(2) and t-BHP potentiated the contraction induced by the Ang II. tert-Butylhydroperoxide 91-96 angiogenin Rattus norvegicus 140-143 20442823-12 2009 H(2)O(2)-induced potentiation of Ang II response may be mediated through tyrosine kinase activation and t-BHP through the activation of cyclo-oxygenase enzyme. tert-Butylhydroperoxide 104-109 angiogenin Rattus norvegicus 33-36