PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20388847-6 2010 Recent results show that metformin-induced activation of AMPK disrupts crosstalk between insulin/IGF-1 receptor and GPCR signaling in pancreatic cancer cells and inhibits the growth of these cells in xenograft models. Metformin 25-34 insulin like growth factor 1 Homo sapiens 97-102 20388847-9 2010 We posit that crosstalk between insulin/IGF-1 receptor and GPCR signaling is a mechanism for promoting the development of certain types of cancer and a target for the prevention and therapy of these diseases via metformin administration. Metformin 212-221 insulin like growth factor 1 Homo sapiens 40-45