PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20226165-4 2010 Celastrol (i) inhibits directly the IKKalpha and beta kinases, (ii) inactivates the Cdc37 and p23 proteins which are co-chaperones of HSP90, (iii) inhibits the function of proteasomes, and (iv) activates the HSF1 and subsequently triggers the heat shock response. celastrol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 134-139