PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20179211-4	2010	DATS significantly attenuated the DNA binding of activator protein-1 (AP-1), one of the transcription factors that regulate COX-2 expression, in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	145-148	jun proto-oncogene	Mus musculus	49-68	
20179211-4	2010	DATS significantly attenuated the DNA binding of activator protein-1 (AP-1), one of the transcription factors that regulate COX-2 expression, in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	145-148	jun proto-oncogene	Mus musculus	70-74	
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	jun proto-oncogene	Mus musculus	47-52	
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	jun proto-oncogene	Mus musculus	92-96	
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	jun proto-oncogene	Mus musculus	36-41	
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	jun proto-oncogene	Mus musculus	120-125	
20179211-9	2010	Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	50-53	jun proto-oncogene	Mus musculus	62-66