PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2015598-11 1991 This strongly suggests that growth inhibition following thymidylate synthase inhibition is mediated through an increase in intracellular dUTP, leading to uracil misincorporation into DNA, its subsequent excision, and resultant strand breakage. Uracil 154-160 thymidylate synthetase Homo sapiens 56-76