PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20153729-6 2010 Our results also indicate that signaling events involved in H-R-enhanced PANC-1 invasiveness comprehend PI3K-dependent activation of Rac1, which mediated the formation of NADPH-generated reactive oxygen species responsible for MMP-2 secretion and activation. NADP 171-176 Rac family small GTPase 1 Homo sapiens 133-137