PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20145128-0 2010 Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. 13c 115-118 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 53-82 20145128-8 2010 Taken together, our findings illustrate the application of hyperpolarized (13)C MRS of pyruvate to monitor alterations in LDHA activity and expression caused by PI3K pathway inhibition, showing the potential of this method for noninvasive imaging of drug target modulation. Pyruvic Acid 87-95 lactate dehydrogenase A Homo sapiens 122-126