PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20097188-8 2010 The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. Nicotine 78-86 acetylcholinesterase Rattus norvegicus 20-40 20097188-8 2010 The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. Nicotine 78-86 acetylcholinesterase Rattus norvegicus 42-46 20097188-13 2010 The current study demonstrated that repeated nicotine exposure could alter CPF metabolism in vivo, resulting in altered brain AChE inhibition. Nicotine 45-53 acetylcholinesterase Rattus norvegicus 126-130