PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20045320-4 2010 Molecular modeling studies showed that the N-difluoromethyl-1,2-dihydropyridin-2-one moiety present in 9a inserts into the secondary pocket present in COX-2 to confer COX-2 selectivity, and that the N-difluoromethyl-1,2-dihydropyrid-2-one group (9a) binds close to the region of the 15-LOX enzyme containing catalytic iron (His361, His366). Iron 318-322 prostaglandin-endoperoxide synthase 2 Homo sapiens 151-156