PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20014870-1 2009 In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5. obeticholic acid 199-227 G protein-coupled bile acid receptor 1 Homo sapiens 50-54 20014870-1 2009 In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5. obeticholic acid 199-227 G protein-coupled bile acid receptor 1 Homo sapiens 271-275 20014870-1 2009 In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5. obeticholic acid 229-236 G protein-coupled bile acid receptor 1 Homo sapiens 50-54