PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20007453-0	2010	Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner.	Superoxides	115-125	tumor necrosis factor	Mus musculus	0-21	
20007453-5	2010	In response to recombinant TNF (rTNF, 20 ng/ml), cardiomyocytes exhibited faster and more pronounced superoxide production compared with cardiofibroblasts, concomitant with increased expression of several MMPs.	Superoxides	101-111	tumor necrosis factor	Mus musculus	27-30	
20007453-10	2010	We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF-mediated events since TNF-induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma.	Superoxides	113-123	tumor necrosis factor	Mus musculus	75-78	
20007453-10	2010	We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF-mediated events since TNF-induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma.	Superoxides	113-123	tumor necrosis factor	Mus musculus	101-104	
20007453-11	2010	We further demonstrated that the TNF-superoxide-MMP axis of events is in fact activated in heart disease in vivo.	Superoxides	37-47	tumor necrosis factor	Mus musculus	33-36	
20007453-13	2010	Our study demonstrates that TNF triggers expression and activation of MMPs faster and stronger in cardiomyocytes than in cardiofibroblasts in a superoxide-dependent manner and via activation of PI3Kgamma, thereby contributing to adverse myocardial remodeling in disease.	Superoxides	144-154	tumor necrosis factor	Mus musculus	28-31