PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19818092-8 2010 On the other hand, the mutant BiP mice showed less morphine tolerance, and the activation of GSK-3b was suppressed in their brain. Morphine 51-59 heat shock protein 5 Mus musculus 30-33 19818092-0 2010 BiP, an endoplasmic reticulum chaperone, modulates the development of morphine antinociceptive tolerance. Morphine 70-78 heat shock protein 5 Mus musculus 0-3 19818092-4 2010 We tested the thermal antinociceptive effect of morphine in heterozygous mutant BiP mice in a hot plate test. Morphine 48-56 heat shock protein 5 Mus musculus 80-83 19818092-9 2010 These results suggest that BiP may play an important role in the development of morphine tolerance. Morphine 80-88 heat shock protein 5 Mus musculus 27-30