PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19759279-10 2009 Exposure to 20 microM caffeine during EWD produced cytotoxicity in all hippocampal regions, though toxicity was sex-dependent in the DG and CA1 region. Caffeine 22-30 carbonic anhydrase 1 Rattus norvegicus 140-143 19759279-12 2009 Similarly, 20 microM caffeine caused markedly greater toxicity in female cultures as compared to male cultures in the CA1 region. Caffeine 21-29 carbonic anhydrase 1 Rattus norvegicus 118-121 19759279-13 2009 CONCLUSIONS: Twenty-four-hour exposure to caffeine during EWD produced significant toxicity in the pyramidal cell layer of the CA3 region in male and female cultures, though toxicity in the granule cell layer of the DG and pyramidal cell layer of the CA1 region was observed only in female cultures. Caffeine 42-50 carbonic anhydrase 1 Rattus norvegicus 251-254