PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1975811-1 1990 The regulation by dexamethasone of beta 1- and beta 2-adrenergic receptor expression during the adipose differentiation of 3T3-F442A cells was investigated at the receptor protein and mRNA level. Dexamethasone 18-31 adrenergic receptor, beta 1 Mus musculus 35-73 1975811-4 1990 Long term exposure of either differentiating cells or mature adipocytes to dexamethasone induced down-regulation of (-)-isoproterenol-sensitive adenylate cyclase activity which paralleled a 2- to 3.5-fold decrease in beta-ARs, while the beta 1/beta 2 ratio switched to approximately 20/80. Dexamethasone 75-88 hemoglobin, beta adult major chain Mus musculus 237-250 1975811-4 1990 Long term exposure of either differentiating cells or mature adipocytes to dexamethasone induced down-regulation of (-)-isoproterenol-sensitive adenylate cyclase activity which paralleled a 2- to 3.5-fold decrease in beta-ARs, while the beta 1/beta 2 ratio switched to approximately 20/80. Isoproterenol 116-133 hemoglobin, beta adult major chain Mus musculus 237-250 1975811-7 1990 The beta 1-AR mRNA (3.2 kilobases) was stimulated 3-4.7 times in differentiated cells, as compared with preadipose cells; this beta 1-AR transcript was repressed in dexamethasone-treated cells. Dexamethasone 165-178 adrenergic receptor, beta 1 Mus musculus 4-13 1975811-7 1990 The beta 1-AR mRNA (3.2 kilobases) was stimulated 3-4.7 times in differentiated cells, as compared with preadipose cells; this beta 1-AR transcript was repressed in dexamethasone-treated cells. Dexamethasone 165-178 adrenergic receptor, beta 1 Mus musculus 127-136 1975811-8 1990 The beta 2-AR mRNA species (2.3 kilobases), absent in preadipocytes, was expressed at low levels in untreated adipocytes, but reached 11-fold this level in dexamethasone-exposed cells. Dexamethasone 156-169 adrenergic receptor, beta 2 Mus musculus 4-13 1975811-9 1990 The switch in receptor subtype protein and mRNA levels elicited by dexamethasone demonstrates the differential genetic control by glucocorticoids of beta-AR subtype expression in 3T3-F442A cells. Dexamethasone 67-80 adrenergic receptor, beta 1 Mus musculus 149-156