PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19716283-0	2010	Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha.	Ascorbic Acid	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	103-113	
19716283-0	2010	Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha.	Testosterone	35-47	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	103-113	
19716283-4	2010	Thus, given that vitamin C inhibits HIF-1alpha expression in several malignant tumors, we examined its therapeutic potential in BPH.	Ascorbic Acid	17-26	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	36-46	
19716283-5	2010	HIF-1alpha was noticeably induced by testosterone in prostate cells, and this HIF-1alpha induction was abolished by vitamin C.	Testosterone	37-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10	
19716283-5	2010	HIF-1alpha was noticeably induced by testosterone in prostate cells, and this HIF-1alpha induction was abolished by vitamin C.	Ascorbic Acid	116-125	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10	
19716283-5	2010	HIF-1alpha was noticeably induced by testosterone in prostate cells, and this HIF-1alpha induction was abolished by vitamin C.	Ascorbic Acid	116-125	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	78-88	
19716283-6	2010	Vascular endothelial growth factor (VEGF) promoter activity reporter assays and semi-quantitative RT-PCR revealed that vitamin C inhibited HIF-1-dependent VEGF expression.	Ascorbic Acid	119-128	vascular endothelial growth factor A	Rattus norvegicus	0-34	
19716283-6	2010	Vascular endothelial growth factor (VEGF) promoter activity reporter assays and semi-quantitative RT-PCR revealed that vitamin C inhibited HIF-1-dependent VEGF expression.	Ascorbic Acid	119-128	vascular endothelial growth factor A	Rattus norvegicus	155-159	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	39-48	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	13-23	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	39-48	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	78-102	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	39-48	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	143-153	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	120-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	13-23	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	120-129	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	78-102	
19716283-7	2010	Furthermore, HIF-1alpha suppression by vitamin C was rescued by knocking down HIF-prolyl hydroxylase-2, suggesting that vitamin C destabilizes HIF-1alpha via prolyl hydroxylation.	Ascorbic Acid	120-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	143-153	
19716283-9	2010	These results suggest that vitamin C inhibits testosterone-induced HIF-1alpha expression and by so doing effectively prevents prostate hyperplasia.	Ascorbic Acid	27-36	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-77	
19716283-9	2010	These results suggest that vitamin C inhibits testosterone-induced HIF-1alpha expression and by so doing effectively prevents prostate hyperplasia.	Testosterone	46-58	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-77	
19716283-12	2010	In vitamin C-treated rats, however, most prostate hyperplasia parameters and prostrate HIF-1alpha/VEGF levels were markedly reduced.	Ascorbic Acid	3-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	87-97	
19716283-12	2010	In vitamin C-treated rats, however, most prostate hyperplasia parameters and prostrate HIF-1alpha/VEGF levels were markedly reduced.	Ascorbic Acid	3-12	vascular endothelial growth factor A	Rattus norvegicus	98-102