PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19681813-1 2009 Tacrolimus, a cornerstone immunosuppressant, is widely available as a twice-daily formulation (Tacrolimus BID). Tacrolimus 0-10 BH3 interacting domain death agonist Homo sapiens 106-109 19681813-1 2009 Tacrolimus, a cornerstone immunosuppressant, is widely available as a twice-daily formulation (Tacrolimus BID). Tacrolimus 95-105 BH3 interacting domain death agonist Homo sapiens 106-109 19681813-3 2009 This study compared the pharmacokinetics (PK) of tacrolimus in de novo kidney transplant patients treated with Tacrolimus QD or Tacrolimus BID. Tacrolimus 49-59 BH3 interacting domain death agonist Homo sapiens 139-142 19681813-9 2009 Mean AUC(0-24) of tacrolimus on day 1 was approximately 30% lower for Tacrolimus QD than Tacrolimus BID (232 and 361 ng.h/mL, respectively), but was comparable by day 4. Tacrolimus 18-28 BH3 interacting domain death agonist Homo sapiens 100-103 19681813-12 2009 Tacrolimus QD can be administered once daily in the morning on the basis of the same systemic exposure and therapeutic drug monitoring concept as Tacrolimus BID. Tacrolimus 0-10 BH3 interacting domain death agonist Homo sapiens 157-160