PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19615983-1	2009	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes.	Methylcholanthrene	179-199	aryl hydrocarbon receptor	Rattus norvegicus	4-29	
19615983-1	2009	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes.	Methylcholanthrene	179-199	aryl hydrocarbon receptor	Rattus norvegicus	31-34	
19615983-1	2009	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes.	Methylcholanthrene	201-203	aryl hydrocarbon receptor	Rattus norvegicus	4-29	
19615983-1	2009	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes.	Methylcholanthrene	201-203	aryl hydrocarbon receptor	Rattus norvegicus	31-34	
19615983-6	2009	To assess whether the observed AHR depletion affected aromatic hydrocarbon responsiveness, the induction of hepatic cytochrome P450 1B1 (CYP1B1) mRNA by MC was measured as an AHR-mediated adaptive response.	Methylcholanthrene	153-155	aryl hydrocarbon receptor	Rattus norvegicus	31-34	
19615983-6	2009	To assess whether the observed AHR depletion affected aromatic hydrocarbon responsiveness, the induction of hepatic cytochrome P450 1B1 (CYP1B1) mRNA by MC was measured as an AHR-mediated adaptive response.	Methylcholanthrene	153-155	aryl hydrocarbon receptor	Rattus norvegicus	175-178	
19615983-9	2009	These data demonstrate that: (1) adrenal-dependent factors contribute to the physiological maintenance of hepatic AHR protein levels; (2) the depletion of hepatic AHR protein in ADX rats coincided with a diminished adaptive response to MC; and (3) exogenous glucocorticoid treatment increases hepatic ARNT mRNA levels regardless of adrenal status.	Methylcholanthrene	236-238	aryl hydrocarbon receptor	Rattus norvegicus	163-166