PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19615353-0 2009 The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. Tryptophan 4-14 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 107-111 19615353-0 2009 The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. Tryptophan 4-14 aryl hydrocarbon receptor 2 Danio rerio 122-126 19615353-0 2009 The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. 6-formylindolo(3,2-b)carbazole 28-58 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 107-111 19615353-0 2009 The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. 6-formylindolo(3,2-b)carbazole 28-58 aryl hydrocarbon receptor 2 Danio rerio 122-126 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). Tryptophan 4-14 aryl hydrocarbon receptor Homo sapiens 138-163 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). Tryptophan 4-14 aryl hydrocarbon receptor Homo sapiens 165-168 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). Tryptophan 4-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 229-248 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). Tryptophan 4-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 250-256 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). 6-formylindolo(3,2-b)carbazole 38-68 aryl hydrocarbon receptor Homo sapiens 138-163 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). 6-formylindolo(3,2-b)carbazole 38-68 aryl hydrocarbon receptor Homo sapiens 165-168 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). 6-formylindolo(3,2-b)carbazole 38-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 229-248 19615353-1 2009 The tryptophan photooxidation product 6-formylindolo[3,2-b]carbazole (FICZ) has been proposed as a physiological ligand for the mammalian aryl hydrocarbon receptor (AHR), which it binds with high-affinity, inducing expression of cytochrome P450 1A1 (CYP1A1). 6-formylindolo(3,2-b)carbazole 38-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 250-256 19615353-6 2009 The 6-h EC(50) values for induction of CYP1A and CYP1B1 by FICZ were 0.6 and 0.5 nM compared to 72-h EC(50) values of 2.3 and 2.7 nM for PCB126, indicating that in zebrafish embryos FICZ is a more potent inducer than PCB126. 3,4,5,3',4'-pentachlorobiphenyl 217-223 cytochrome P450, family 1, subfamily A Danio rerio 39-44 19615353-6 2009 The 6-h EC(50) values for induction of CYP1A and CYP1B1 by FICZ were 0.6 and 0.5 nM compared to 72-h EC(50) values of 2.3 and 2.7 nM for PCB126, indicating that in zebrafish embryos FICZ is a more potent inducer than PCB126. 3,4,5,3',4'-pentachlorobiphenyl 217-223 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 49-55 19615353-7 2009 FICZ at 10 nM was able to completely displace binding of 2,3,7,8-tetrachloro-1,6[3H]-dibenzo-p-dioxin to in vitro-expressed zebrafish AHR2 and AHR1B. 2,3,7,8-tetrachloro-1,6[3h]-dibenzo-p-dioxin 57-101 aryl hydrocarbon receptor 2 Danio rerio 134-138 19615353-7 2009 FICZ at 10 nM was able to completely displace binding of 2,3,7,8-tetrachloro-1,6[3H]-dibenzo-p-dioxin to in vitro-expressed zebrafish AHR2 and AHR1B. 2,3,7,8-tetrachloro-1,6[3h]-dibenzo-p-dioxin 57-101 aryl hydrocarbon receptor 1b Danio rerio 143-148 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Morpholinos 72-82 aryl hydrocarbon receptor 2 Danio rerio 14-18 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Morpholinos 72-82 aryl hydrocarbon receptor 2 Danio rerio 58-62 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Morpholinos 72-82 cytochrome P450, family 1, subfamily A Danio rerio 136-141 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Morpholinos 72-82 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 146-152 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Oligonucleotides 93-108 aryl hydrocarbon receptor 2 Danio rerio 14-18 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Oligonucleotides 93-108 aryl hydrocarbon receptor 2 Danio rerio 58-62 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Oligonucleotides 93-108 cytochrome P450, family 1, subfamily A Danio rerio 136-141 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. Oligonucleotides 93-108 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 146-152 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. 3,4,5,3',4'-pentachlorobiphenyl 168-174 aryl hydrocarbon receptor 2 Danio rerio 14-18 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. 3,4,5,3',4'-pentachlorobiphenyl 168-174 aryl hydrocarbon receptor 2 Danio rerio 58-62 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. 3,4,5,3',4'-pentachlorobiphenyl 168-174 cytochrome P450, family 1, subfamily A Danio rerio 136-141 19615353-8 2009 Inhibition of AHR2 translation in zebrafish embryos by an AHR2-specific morpholino antisense oligonucleotide decreased the induction of CYP1A and CYP1B1 by FICZ and by PCB126. 3,4,5,3',4'-pentachlorobiphenyl 168-174 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 146-152