PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19476543-0	2009	Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone.	Nicotine	42-50	tyrosine hydroxylase	Rattus norvegicus	13-33	
19476543-1	2009	Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain.	Nicotine	9-17	tyrosine hydroxylase	Rattus norvegicus	41-61	
19476543-1	2009	Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain.	Nicotine	9-17	tyrosine hydroxylase	Rattus norvegicus	63-65	
19476543-3	2009	In both models nicotine stimulates TH gene transcription rate in a dose-dependent manner.	Nicotine	15-23	tyrosine hydroxylase	Rattus norvegicus	35-37	
19476543-5	2009	Nicotine elevates circulating glucocorticoids, which induce TH expression in some model systems.	Nicotine	0-8	tyrosine hydroxylase	Rattus norvegicus	60-62	
19476543-6	2009	We tested the hypothesis that the effect of nicotine on midbrain TH mRNA is mediated by the glucocorticoid receptor.	Nicotine	44-52	tyrosine hydroxylase	Rattus norvegicus	65-67	
19476543-7	2009	When rats are administered the glucocorticoid receptor antagonist mifepristone, the induction of TH mRNA by nicotine in both substantia nigra and ventral tegmentum is inhibited.	Nicotine	108-116	tyrosine hydroxylase	Rattus norvegicus	97-99	
19476543-9	2009	Our results are consistent with the hypothesis that nicotine induces TH mRNA in midbrain by elevating glucocorticoids, which then act on glucocorticoid receptors in dopamine neurons leading to transcriptional activation of the TH gene.	Nicotine	52-60	tyrosine hydroxylase	Rattus norvegicus	69-71	
19476543-9	2009	Our results are consistent with the hypothesis that nicotine induces TH mRNA in midbrain by elevating glucocorticoids, which then act on glucocorticoid receptors in dopamine neurons leading to transcriptional activation of the TH gene.	Nicotine	52-60	tyrosine hydroxylase	Rattus norvegicus	227-229