PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19474057-2 2009 One suggestion is that increased DHEA production by P450c17 (CYP17A1 as listed in HUGO Database) in the ZR results from a coincident fall in the expression of HSD3B, which would otherwise compete for pregnenolone substrate. Dehydroepiandrosterone 33-37 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 19474057-3 2009 Nonetheless, studies of human and rhesus adrenal show that cytochrome b5 (CYTB5) expression increases in the ZR with DHEA biosynthesis, and cloned human and rhesus P450c17 show selective increases in 17,20-lyase activity in the presence of CYTB5. Dehydroepiandrosterone 117-121 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-171