PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19263259-6 2009 Consistent with the clamp data, the extent of insulin receptor substrate (IRS)-1 tyrosine phosphorylation in response to insulin was significantly enhanced in the liver and adipose tissues. Tyrosine 81-89 insulin receptor substrate 1 Rattus norvegicus 46-80 19263259-8 2009 CONCLUSION: These results demonstrate that visfatin/PBEF/Nampt improves insulin sensitivity and exerts its hypocholesterolemic effects at least partially through upregulation of the tyrosine phosphorylation of IRS-1 protein and the mRNA levels of PPARgamma and SREBP-2. Tyrosine 182-190 insulin receptor substrate 1 Rattus norvegicus 210-215