PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19195913-0	2009	Hyaluronan promotes the chondrocyte response to BMP-7.	Hyaluronic Acid	0-10	bone morphogenetic protein 7	Bos taurus	48-53	
19195913-4	2009	The purpose of this study was to determine the ability of hyaluronan in the pericellular matrix to modulate the chondrocyte responses to BMP-7 or TGF-beta1.	Hyaluronic Acid	58-68	bone morphogenetic protein 7	Bos taurus	137-142	
19195913-4	2009	The purpose of this study was to determine the ability of hyaluronan in the pericellular matrix to modulate the chondrocyte responses to BMP-7 or TGF-beta1.	Hyaluronic Acid	58-68	transforming growth factor beta 1	Bos taurus	146-155	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	SMAD family member 1	Bos taurus	147-152	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	SMAD family member 4	Bos taurus	157-162	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	bone morphogenetic protein 7	Bos taurus	178-183	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	SMAD family member 2	Bos taurus	223-228	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	SMAD family member 4	Bos taurus	233-238	
19195913-7	2009	RESULTS: The disruption of the hyaluronan-dependent pericellular matrix of chondrocytes resulted in diminished nuclear translocation of endogenous Smad1 and Smad4 in response to BMP-7; however, the nuclear translocation of Smad2 and Smad4 in these matrix-depleted chondrocytes in response to TGF-beta1 was not diminished.	Hyaluronic Acid	31-41	transforming growth factor beta 1	Bos taurus	292-301	
19195913-8	2009	Incubation of the matrix-depleted chondrocytes with exogenous hyaluronan restored Smad1 and Smad4 nuclear translocation and increased pCD44(499)-Luc luciferase expression in response to BMP-7.	Hyaluronic Acid	62-72	SMAD family member 1	Bos taurus	82-87	
19195913-8	2009	Incubation of the matrix-depleted chondrocytes with exogenous hyaluronan restored Smad1 and Smad4 nuclear translocation and increased pCD44(499)-Luc luciferase expression in response to BMP-7.	Hyaluronic Acid	62-72	SMAD family member 4	Bos taurus	92-97	
19195913-8	2009	Incubation of the matrix-depleted chondrocytes with exogenous hyaluronan restored Smad1 and Smad4 nuclear translocation and increased pCD44(499)-Luc luciferase expression in response to BMP-7.	Hyaluronic Acid	62-72	bone morphogenetic protein 7	Bos taurus	186-191	
19195913-9	2009	Both exogenous hyaluronan and matrix re-growth enhanced by hyaluronan synthase-2 (HAS2) transfection restored Smad1 phosphorylation.	Hyaluronic Acid	15-25	hyaluronan synthase 2	Bos taurus	59-80	
19195913-9	2009	Both exogenous hyaluronan and matrix re-growth enhanced by hyaluronan synthase-2 (HAS2) transfection restored Smad1 phosphorylation.	Hyaluronic Acid	15-25	hyaluronan synthase 2	Bos taurus	82-86	
19195913-9	2009	Both exogenous hyaluronan and matrix re-growth enhanced by hyaluronan synthase-2 (HAS2) transfection restored Smad1 phosphorylation.	Hyaluronic Acid	15-25	SMAD family member 1	Bos taurus	110-115	
19195913-10	2009	CONCLUSIONS: Disruption of hyaluronan-CD44 interactions has little effect on the TGF-beta responses; however, re-establishing CD44-hyaluronan ligation promotes a robust cellular response to BMP-7 by articular chondrocytes.	Hyaluronic Acid	27-37	CD44 molecule	Bos taurus	38-42	
19195913-11	2009	Thus, changes in cell-hyaluronan interactions may serve as a mechanism to modulate cellular responsiveness to BMP-7.	Hyaluronic Acid	22-32	bone morphogenetic protein 7	Bos taurus	110-115