PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19147120-0	2009	Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-54	
19147120-2	2009	We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts.	Nicotine	94-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-141	
19147120-2	2009	We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts.	Nicotine	94-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	143-148	
19147120-3	2009	Nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA in a time- and dose-dependent manner.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-73	
19147120-4	2009	The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%.	Nicotine	4-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-77	
19147120-8	2009	These results suggest that nicotine is taken up by human gingival fibroblasts and that it then stimulates COX-2 expression via the activation of NFkappaB and the subsequent release of prostaglandin E(2).	Nicotine	27-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-111