PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19098447-0 2009 Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. safingol 0-8 proline rich transmembrane protein 2 Homo sapiens 92-95 19098447-5 2009 Conversely, activation of PKCs with phorbol 12,13-dibutyrate (PDBu) or transient transfection of a constitutively active form of Akt each reduced safingol"s autophagic induction, but not completely, indicating that Akt- and PKC-dependent pathways both contribute partially and independently to safingol-induced autophagy. safingol 146-154 proline rich transmembrane protein 2 Homo sapiens 26-29 19098447-5 2009 Conversely, activation of PKCs with phorbol 12,13-dibutyrate (PDBu) or transient transfection of a constitutively active form of Akt each reduced safingol"s autophagic induction, but not completely, indicating that Akt- and PKC-dependent pathways both contribute partially and independently to safingol-induced autophagy. safingol 294-302 proline rich transmembrane protein 2 Homo sapiens 26-29