PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18927207-1 2009 GPR40 is a G protein-coupled receptor (GPCR) whose endogenous ligands have recently been identified as medium- and long-chain free fatty acids (FFAs), and it is thought to play an important role in insulin release. medium- and long-chain free fatty acids 103-142 free fatty acid receptor 1 Mus musculus 0-5 18927207-6 2009 The FFAs that activate GPR40 competed with C1-BODIPY-C12 binding; thus, medium- to long-chain FFAs could compete, whereas short-chain FFAs and methyl linoleate had no inhibitory effect. C1-BODIPY-C12 43-56 free fatty acid receptor 1 Mus musculus 23-28 18927207-6 2009 The FFAs that activate GPR40 competed with C1-BODIPY-C12 binding; thus, medium- to long-chain FFAs could compete, whereas short-chain FFAs and methyl linoleate had no inhibitory effect. methyl linoleate 143-159 free fatty acid receptor 1 Mus musculus 23-28 18927207-8 2009 All the ligands that inhibited the binding promoted phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in human embryonic kidney (HEK) 293 cells that expressed GPR40 and [Ca(2+)](i) responses in mouse insulinoma (MIN6) cells that natively express GPR40; however, pioglitazone, a thiazolidinedione that failed to compete for the binding, did not activate ERK or [Ca(2+)](i) response. Pioglitazone 279-291 mitogen-activated protein kinase 3 Homo sapiens 71-118 18927207-8 2009 All the ligands that inhibited the binding promoted phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in human embryonic kidney (HEK) 293 cells that expressed GPR40 and [Ca(2+)](i) responses in mouse insulinoma (MIN6) cells that natively express GPR40; however, pioglitazone, a thiazolidinedione that failed to compete for the binding, did not activate ERK or [Ca(2+)](i) response. Pioglitazone 279-291 mitogen-activated protein kinase 1 Mus musculus 110-113 18927207-8 2009 All the ligands that inhibited the binding promoted phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in human embryonic kidney (HEK) 293 cells that expressed GPR40 and [Ca(2+)](i) responses in mouse insulinoma (MIN6) cells that natively express GPR40; however, pioglitazone, a thiazolidinedione that failed to compete for the binding, did not activate ERK or [Ca(2+)](i) response. 2,4-thiazolidinedione 295-312 mitogen-activated protein kinase 3 Homo sapiens 71-118 18927207-8 2009 All the ligands that inhibited the binding promoted phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in human embryonic kidney (HEK) 293 cells that expressed GPR40 and [Ca(2+)](i) responses in mouse insulinoma (MIN6) cells that natively express GPR40; however, pioglitazone, a thiazolidinedione that failed to compete for the binding, did not activate ERK or [Ca(2+)](i) response. 2,4-thiazolidinedione 295-312 mitogen-activated protein kinase 1 Mus musculus 110-113