PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18771379-7 2008 RESULTS: The secretion of IL-1beta and -8 and TNF-alpha by macrophages decreased significantly (P <0.05) when they were pretreated with 2 microM doxycycline, whereas a concentration of 10 microM was required to significantly reduce IL-6 secretion. Doxycycline 148-159 interleukin 6 Homo sapiens 235-239