PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18729006-7 2008 While it is understood that G6PD-derived NADPH, which is a cofactor for NADPH oxidase, enhances superoxide anion generation and elevates oxidative stress in diabetes, heart failure, and angiotensin II-induced hypertrophy of smooth muscle, there are no specific drugs available to study the role of G6PD and G6PD-derived NADPH in organ function and the development of human diseases. Superoxides 96-112 glucose-6-phosphate dehydrogenase Homo sapiens 28-32