PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18701486-3 2008 Importantly, K-ras and erbb2 elicit a similar ERK-mediated activation of cysteine cathepsins, cathepsin-dependent down-regulation of LAMPs, and increased drug sensitivity in human colon and breast carcinoma cells, respectively. Cysteine 73-81 KRAS proto-oncogene, GTPase Homo sapiens 13-18 18701486-3 2008 Importantly, K-ras and erbb2 elicit a similar ERK-mediated activation of cysteine cathepsins, cathepsin-dependent down-regulation of LAMPs, and increased drug sensitivity in human colon and breast carcinoma cells, respectively. Cysteine 73-81 erb-b2 receptor tyrosine kinase 2 Homo sapiens 23-28 18701486-3 2008 Importantly, K-ras and erbb2 elicit a similar ERK-mediated activation of cysteine cathepsins, cathepsin-dependent down-regulation of LAMPs, and increased drug sensitivity in human colon and breast carcinoma cells, respectively. Cysteine 73-81 mitogen-activated protein kinase 1 Homo sapiens 46-49 18701486-5 2008 Furthermore, knockdown of either lamp1 or lamp2 is sufficient to sensitize the cells to siramesine-induced cell death and photo-oxidation-induced lysosomal destabilization. Lu 28-179 88-98 lysosomal associated membrane protein 1 Homo sapiens 33-38 18701486-5 2008 Furthermore, knockdown of either lamp1 or lamp2 is sufficient to sensitize the cells to siramesine-induced cell death and photo-oxidation-induced lysosomal destabilization. Lu 28-179 88-98 lysosomal associated membrane protein 2 Homo sapiens 42-47