PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18684927-0	2008	Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Polychlorinated Dibenzodioxins	121-156	CD4 antigen	Mus musculus	60-63	
18684927-0	2008	Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Polychlorinated Dibenzodioxins	121-156	interleukin 2 receptor, alpha chain	Mus musculus	65-69	
18684927-1	2008	Although the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through binding and activation of the aryl hydrocarbon receptor (AhR), the subsequent biochemical and molecular changes that confer immune suppression are not well understood.	Polychlorinated Dibenzodioxins	24-59	aryl-hydrocarbon receptor	Mus musculus	118-143	
18684927-1	2008	Although the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through binding and activation of the aryl hydrocarbon receptor (AhR), the subsequent biochemical and molecular changes that confer immune suppression are not well understood.	Polychlorinated Dibenzodioxins	24-59	aryl-hydrocarbon receptor	Mus musculus	145-148	
18684927-1	2008	Although the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through binding and activation of the aryl hydrocarbon receptor (AhR), the subsequent biochemical and molecular changes that confer immune suppression are not well understood.	Polychlorinated Dibenzodioxins	61-65	aryl-hydrocarbon receptor	Mus musculus	118-143	
18684927-1	2008	Although the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through binding and activation of the aryl hydrocarbon receptor (AhR), the subsequent biochemical and molecular changes that confer immune suppression are not well understood.	Polychlorinated Dibenzodioxins	61-65	aryl-hydrocarbon receptor	Mus musculus	145-148	
18684927-2	2008	Mice exposed to TCDD during an acute B6-into-B6D2F1 graft-vs-host response do not develop disease, and recently this has been shown to correlate with the generation of CD4(+) T cells that express CD25 and demonstrate in vitro suppressive function.	Polychlorinated Dibenzodioxins	16-20	CD4 antigen	Mus musculus	168-171	
18684927-2	2008	Mice exposed to TCDD during an acute B6-into-B6D2F1 graft-vs-host response do not develop disease, and recently this has been shown to correlate with the generation of CD4(+) T cells that express CD25 and demonstrate in vitro suppressive function.	Polychlorinated Dibenzodioxins	16-20	interleukin 2 receptor, alpha chain	Mus musculus	196-200	
18684927-5	2008	We found that TCDD-CD4(+) cells actively proliferate in response to various stimuli but suppress IL-2 production and the proliferation of effector T cells.	Polychlorinated Dibenzodioxins	14-18	CD4 antigen	Mus musculus	19-22	
18684927-5	2008	We found that TCDD-CD4(+) cells actively proliferate in response to various stimuli but suppress IL-2 production and the proliferation of effector T cells.	Polychlorinated Dibenzodioxins	14-18	interleukin 2	Mus musculus	97-101	
18684927-6	2008	Like natural T-regs, TCDD-CD4(+) cells do not produce IL-2 and their suppressive function is contact dependent but abrogated by costimulation through glucocorticoid-induced TNFR (GITR).	Polychlorinated Dibenzodioxins	21-25	CD4 antigen	Mus musculus	26-29	
18684927-8	2008	Several genes were significantly up-regulated in TCDD-CD4(+) cells including TGF-beta3, Blimp-1, and granzyme B, as well as genes associated with the IL12-Rb2 signaling pathway.	Polychlorinated Dibenzodioxins	49-53	CD4 antigen	Mus musculus	54-57	
18684927-8	2008	Several genes were significantly up-regulated in TCDD-CD4(+) cells including TGF-beta3, Blimp-1, and granzyme B, as well as genes associated with the IL12-Rb2 signaling pathway.	Polychlorinated Dibenzodioxins	49-53	transforming growth factor, beta 3	Mus musculus	77-86	
18684927-8	2008	Several genes were significantly up-regulated in TCDD-CD4(+) cells including TGF-beta3, Blimp-1, and granzyme B, as well as genes associated with the IL12-Rb2 signaling pathway.	Polychlorinated Dibenzodioxins	49-53	PR domain containing 1, with ZNF domain	Mus musculus	88-95	
18684927-8	2008	Several genes were significantly up-regulated in TCDD-CD4(+) cells including TGF-beta3, Blimp-1, and granzyme B, as well as genes associated with the IL12-Rb2 signaling pathway.	Polychlorinated Dibenzodioxins	49-53	granzyme B	Mus musculus	101-111	
18684927-10	2008	Only 2% of TCDD-CD4(+) cells express Foxp3, suggesting that the AhR does not rely on Foxp3 for suppressive activity.	Polychlorinated Dibenzodioxins	11-15	CD4 antigen	Mus musculus	16-19	
18684927-11	2008	The generation of CD4(+) cells with regulatory function mediated through activation of the AhR by TCDD may represent a novel pathway for the induction of T-regs.	Polychlorinated Dibenzodioxins	98-102	CD4 antigen	Mus musculus	18-21	
18684927-11	2008	The generation of CD4(+) cells with regulatory function mediated through activation of the AhR by TCDD may represent a novel pathway for the induction of T-regs.	Polychlorinated Dibenzodioxins	98-102	aryl-hydrocarbon receptor	Mus musculus	91-94