PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18682391-5	2008	Histamine also rapidly and transiently activates protein kinase C-delta (PKCdelta), extracellular signal-regulated kinase (ERK)1/2, p38 kinase, and c-Jun N-terminal kinase (JNK) prior to Egr-1 induction.	Histamine	0-9	protein kinase C delta	Homo sapiens	73-81	
18682391-6	2008	Using specific pharmacological inhibitors and small interfering RNA technology, we determined that PKCdelta and ERK, but not p38 and JNK, mediate histamine-induced Egr-1 expression.	Histamine	146-155	protein kinase C delta	Homo sapiens	99-107	
18682391-8	2008	The present study reveals the following regulatory mechanism: histamine up-regulates Egr-1 expression in primary HAECs via the H1 receptor and the PKCdelta-dependent ERK activation pathway.	Histamine	62-71	protein kinase C delta	Homo sapiens	147-155