PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18674879-5 2008 Hypoxia and iron chelator 2,2"-dipyridyl treatment can stimulate the invasion and migration enhancement of Lovo cells, while resveratrol exhibited substantial resistance on the metastasis potential stimulation by inhibiting the mRNA expression of VEGF and MMP-9 in colon carcinoma cells under normoxia and hypoxia, reducing HIF-1 alpha protein expression under hypoxia. Resveratrol 125-136 hypoxia inducible factor 1 subunit alpha Homo sapiens 324-335 18674879-7 2008 These data demonstrated that, the antimetastatic effect of resveratrol under hypoxia were associated with the restriction of HIF-1 alpha protein expression and stabilization, which could be a promising drug target for resveratrol in the development of an effective chemopreventive and anticancer therapy in human tumors. Resveratrol 59-70 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-136 18674879-7 2008 These data demonstrated that, the antimetastatic effect of resveratrol under hypoxia were associated with the restriction of HIF-1 alpha protein expression and stabilization, which could be a promising drug target for resveratrol in the development of an effective chemopreventive and anticancer therapy in human tumors. Resveratrol 218-229 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-136