PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18578558-6 2008 Because de novo immunosuppression uses CNI in more than 93% of patients, reduction of CNI-related adverse effects has focused on CNI sparing or withdrawal.A recurring theme where sirolimus and mycophenolate mofetil have been used for this purpose is the importance of their early introduction to limit CNI damage and provide long-term benefit: for example, long-term renal function critically reflects that at 1 year post-transplant. Sirolimus 179-188 5'-nucleotidase, cytosolic IA Homo sapiens 39-42 18578558-6 2008 Because de novo immunosuppression uses CNI in more than 93% of patients, reduction of CNI-related adverse effects has focused on CNI sparing or withdrawal.A recurring theme where sirolimus and mycophenolate mofetil have been used for this purpose is the importance of their early introduction to limit CNI damage and provide long-term benefit: for example, long-term renal function critically reflects that at 1 year post-transplant. Sirolimus 179-188 5'-nucleotidase, cytosolic IA Homo sapiens 86-89 18578558-6 2008 Because de novo immunosuppression uses CNI in more than 93% of patients, reduction of CNI-related adverse effects has focused on CNI sparing or withdrawal.A recurring theme where sirolimus and mycophenolate mofetil have been used for this purpose is the importance of their early introduction to limit CNI damage and provide long-term benefit: for example, long-term renal function critically reflects that at 1 year post-transplant. Sirolimus 179-188 5'-nucleotidase, cytosolic IA Homo sapiens 86-89