PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18559349-0	2008	Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.	Tyrosine	44-52	angiotensinogen	Homo sapiens	93-107	
18559349-2	2008	Here, we demonstrate that, in MCs, Ang II induces an increase in PDK-1 (3-phosphoinositide-dependent protein kinase-1) kinase activity that required its phosphorylation on tyrosine 9 and 373/376.	Tyrosine	172-180	angiotensinogen	Homo sapiens	35-41	
18559349-3	2008	Introduction into the cells of PDK-1, mutated on these tyrosine residues or kinase-inactive, attenuates Ang II-induced hypertrophy and fibronectin accumulation.	Tyrosine	55-63	angiotensinogen	Homo sapiens	104-110	
18559349-7	2008	Small interfering RNA for Nox4 also inhibits Ang II-induced activation of Src and PDK-1 tyrosine phosphorylation (total and on residues 9 and 373/376), demonstrating that Nox4 functions upstream of Src and PDK-1.	Tyrosine	88-96	angiotensinogen	Homo sapiens	45-51	
18559349-9	2008	This work provides the first evidence that Nox4-derived ROS are responsible for Ang II-induced PDK-1 tyrosine phosphorylation and activation through stimulation of Src.	Tyrosine	101-109	angiotensinogen	Homo sapiens	80-86