PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18485875-2 2008 We previously showed that GzmA acts directly on mitochondria to generate reactive oxygen species (ROS) and disrupt the transmembrane potential (DeltaPsi(m)) but does not permeabilize the mitochondrial outer membrane. Reactive Oxygen Species 73-96 granzyme A Homo sapiens 26-30 18485875-2 2008 We previously showed that GzmA acts directly on mitochondria to generate reactive oxygen species (ROS) and disrupt the transmembrane potential (DeltaPsi(m)) but does not permeabilize the mitochondrial outer membrane. Reactive Oxygen Species 98-101 granzyme A Homo sapiens 26-30 18485875-3 2008 Mitochondrial damage is critical to GzmA-induced cell death since cells treated with superoxide scavengers are resistant to GzmA. Superoxides 85-95 granzyme A Homo sapiens 36-40 18485875-3 2008 Mitochondrial damage is critical to GzmA-induced cell death since cells treated with superoxide scavengers are resistant to GzmA. Superoxides 85-95 granzyme A Homo sapiens 124-128 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Iron 100-104 granzyme A Homo sapiens 18-22 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Iron 100-104 NADH:ubiquinone oxidoreductase core subunit S3 Homo sapiens 89-95 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Sulfur 105-111 granzyme A Homo sapiens 18-22 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Sulfur 105-111 NADH:ubiquinone oxidoreductase core subunit S3 Homo sapiens 89-95 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. NAD 127-131 granzyme A Homo sapiens 18-22 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. NAD 127-131 NADH:ubiquinone oxidoreductase core subunit S3 Homo sapiens 89-95 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. NAD 199-203 granzyme A Homo sapiens 18-22 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. NAD 199-203 NADH:ubiquinone oxidoreductase core subunit S3 Homo sapiens 89-95 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Superoxides 227-244 granzyme A Homo sapiens 18-22 18485875-4 2008 Here we find that GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I, after Lys56 to interfere with NADH oxidation and generate superoxide anions. Superoxides 227-244 NADH:ubiquinone oxidoreductase core subunit S3 Homo sapiens 89-95