PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18468445-2	2008	To overcome metabolic instability and poor membrane permeability, the N- and C-termini of Endo-1 were modified by lipoamino acids (Laa) and/or sugars, and 2",6"-dimethyltyrosine (Dmt) replacement of Tyr.	2',6'-dimethyltyrosine	155-177	ENDO1	Homo sapiens	90-96	
18468445-2	2008	To overcome metabolic instability and poor membrane permeability, the N- and C-termini of Endo-1 were modified by lipoamino acids (Laa) and/or sugars, and 2",6"-dimethyltyrosine (Dmt) replacement of Tyr.	2',6'-dimethyltyrosine	179-182	ENDO1	Homo sapiens	90-96	
18468445-5	2008	Dmt provided a promising lead compound: [C8Laa-Dmt[1]]-Endo-1 is nine times more stable (t(1/2)=43.5min), >8-fold more permeable in Caco-2 cell monolayers, and exhibits 140-fold greater mu-opioid receptor affinity (K(imu)=0.08nM).	2',6'-dimethyltyrosine	0-3	ENDO1	Homo sapiens	55-61