PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18362147-0	2008	Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65.	Tyrosine	141-149	coagulation factor II, thrombin	Homo sapiens	54-62	
18362147-4	2008	Stimulation of human vascular endothelial cells with thrombin resulted in a time-dependent phosphorylation of Syk on tyrosine 525 and 526, an indication of Syk activation.	Tyrosine	117-125	coagulation factor II, thrombin	Homo sapiens	53-61	
18362147-10	2008	Thus, these data unveil a novel pathway in which Syk signals downstream of PKC-delta to mediate thrombin induced ICAM-1 expression in endothelial cells by increasing transcriptional capacity of NF-kappaB via a mechanism that relies on tyrosine phosphorylation of RelA/p65.	Tyrosine	235-243	coagulation factor II, thrombin	Homo sapiens	96-104