PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18234185-5 2008 In the present experiment, therefore, we examined (1) a role of the brain 2-arachidonoyl-sn-glycerol as a precursor of arachidonic acid in the centrally administered vasopressin-induced elevation of plasma noradrenaline and adrenaline, and (2) a regulatory role of the brain 2-arachidonoyl-sn-glycerol as an endocannabinoid on the vasopressin-induced response, using urethane-anesthetized rats. Arachidonic Acid 119-135 arginine vasopressin Rattus norvegicus 166-177 18234185-18 2008 These results suggest that the brain 2-arachidonoyl-sn-glycerol generated from diacylglycerol plays a role as a precursor of arachidonic acid in the centrally administered vasopressin-induced activation of the adrenomedullary outflow, and also negatively regulates the peptide-induced central response through the brain cannabinoid CB(1) receptors in rats. Arachidonic Acid 125-141 arginine vasopressin Rattus norvegicus 172-183