PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18188632-0	2008	Apoptotic effects of dietary and synthetic sphingolipids in androgen-independent (PC-3) prostate cancer cells.	Sphingolipids	43-56	BTG anti-proliferation factor 2	Homo sapiens	82-86	
18188632-3	2008	The results of the present study demonstrate that natural (CerPCho, C18-ceramide) and synthetic (C6-ceramide) sphingolipids reduced PC-3 cell proliferation by 15 +/- 1.8, 17 +/- 2.5, and 46 +/- 2.1%, respectively (P < 0.05).	cerpcho	59-66	BTG anti-proliferation factor 2	Homo sapiens	132-136	
18188632-3	2008	The results of the present study demonstrate that natural (CerPCho, C18-ceramide) and synthetic (C6-ceramide) sphingolipids reduced PC-3 cell proliferation by 15 +/- 1.8, 17 +/- 2.5, and 46 +/- 2.1%, respectively (P < 0.05).	C18-CERAMIDE	68-80	BTG anti-proliferation factor 2	Homo sapiens	132-136	
18188632-3	2008	The results of the present study demonstrate that natural (CerPCho, C18-ceramide) and synthetic (C6-ceramide) sphingolipids reduced PC-3 cell proliferation by 15 +/- 1.8, 17 +/- 2.5, and 46 +/- 2.1%, respectively (P < 0.05).	N-caproylsphingosine	97-108	BTG anti-proliferation factor 2	Homo sapiens	132-136	
18188632-3	2008	The results of the present study demonstrate that natural (CerPCho, C18-ceramide) and synthetic (C6-ceramide) sphingolipids reduced PC-3 cell proliferation by 15 +/- 1.8, 17 +/- 2.5, and 46 +/- 2.1%, respectively (P < 0.05).	Sphingolipids	110-123	BTG anti-proliferation factor 2	Homo sapiens	132-136	
18188632-5	2008	Treatment of PC-3 cells with CerPCho and C18-ceramide significantly increased apoptosis by 3.0 +/- 0.8 and 3.6 +/- 0.6%, respectively, compared to the untreated control, while the synthetic C6-ceramide significantly increased apoptosis by 55.7 +/- 0.4%.	cerpcho	29-36	BTG anti-proliferation factor 2	Homo sapiens	13-17	
18188632-5	2008	Treatment of PC-3 cells with CerPCho and C18-ceramide significantly increased apoptosis by 3.0 +/- 0.8 and 3.6 +/- 0.6%, respectively, compared to the untreated control, while the synthetic C6-ceramide significantly increased apoptosis by 55.7 +/- 0.4%.	C18-CERAMIDE	41-53	BTG anti-proliferation factor 2	Homo sapiens	13-17	
18188632-5	2008	Treatment of PC-3 cells with CerPCho and C18-ceramide significantly increased apoptosis by 3.0 +/- 0.8 and 3.6 +/- 0.6%, respectively, compared to the untreated control, while the synthetic C6-ceramide significantly increased apoptosis by 55.7 +/- 0.4%.	N-caproylsphingosine	190-201	BTG anti-proliferation factor 2	Homo sapiens	13-17	
18188632-6	2008	C6-ceramide-induced apoptosis was associated with cell cycle arrest in the G(2)/M phase, decreased extracellular signal-regulated kinase (ERK1/2) signaling and activation of the cell cycle regulatory protein, retinoblastoma (pRb).	N-caproylsphingosine	0-11	mitogen-activated protein kinase 3	Homo sapiens	138-144	
18188632-6	2008	C6-ceramide-induced apoptosis was associated with cell cycle arrest in the G(2)/M phase, decreased extracellular signal-regulated kinase (ERK1/2) signaling and activation of the cell cycle regulatory protein, retinoblastoma (pRb).	N-caproylsphingosine	0-11	RB transcriptional corepressor 1	Homo sapiens	209-223	
18188632-6	2008	C6-ceramide-induced apoptosis was associated with cell cycle arrest in the G(2)/M phase, decreased extracellular signal-regulated kinase (ERK1/2) signaling and activation of the cell cycle regulatory protein, retinoblastoma (pRb).	N-caproylsphingosine	0-11	RB transcriptional corepressor 1	Homo sapiens	225-228	
18188632-7	2008	Treatment of PC-3 cells with C18-ceramide and CerPCho did not alter cell cycle distribution, pRb or ERK1/2 activation.	C18-CERAMIDE	29-41	BTG anti-proliferation factor 2	Homo sapiens	13-17	
18188632-8	2008	Taken together, these results suggest that natural and synthetic sphingolipids induce apoptosis in PC-3 cells via distinct signaling mechanisms and potencies.	Sphingolipids	65-78	BTG anti-proliferation factor 2	Homo sapiens	99-103