PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18162070-0	2008	Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley rats.	Ethanol	123-130	proopiomelanocortin	Rattus norvegicus	98-107	
18162070-2	2008	Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake.	Ethanol	121-128	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	56-67	
18162070-2	2008	Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake.	Ethanol	121-128	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	69-72	
18162070-2	2008	Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake.	Ethanol	133-140	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	56-67	
18162070-2	2008	Recent pharmacologic and genetic evidence suggests that MC receptor (MCR) signaling modulates neurobiologic responses to ethanol and ethanol intake.	Ethanol	133-140	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	69-72	
18162070-3	2008	Because ethanol decreases POMC mRNA levels, we determined if exposure to an ethanol-containing diet (ED) would significantly reduce central immunoreactivity of the MC peptide alpha-MSH in rats.	Ethanol	8-15	proopiomelanocortin	Rattus norvegicus	26-30	
18162070-3	2008	Because ethanol decreases POMC mRNA levels, we determined if exposure to an ethanol-containing diet (ED) would significantly reduce central immunoreactivity of the MC peptide alpha-MSH in rats.	Ethanol	76-83	proopiomelanocortin	Rattus norvegicus	26-30	
18162070-3	2008	Because ethanol decreases POMC mRNA levels, we determined if exposure to an ethanol-containing diet (ED) would significantly reduce central immunoreactivity of the MC peptide alpha-MSH in rats.	Ethanol	76-83	proopiomelanocortin	Rattus norvegicus	175-184	
18162070-4	2008	We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist.	Ethanol	22-29	agouti related neuropeptide	Rattus norvegicus	75-97	
18162070-4	2008	We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist.	Ethanol	22-29	agouti related neuropeptide	Rattus norvegicus	99-103	
18162070-8	2008	Ethanol-induced reductions of alpha-MSH immunoreactivity were site-specific and were noted in regions of the hypothalamus and extended amygdala, as well as the paraventricular nucleus of the thalamus.	Ethanol	0-7	proopiomelanocortin	Rattus norvegicus	30-39	
18162070-9	2008	Because there were no differences in body weights or caloric intake between the CD and ED groups, reductions of alpha-MSH immunoreactivity in ED-treated rats are best explained by ethanol exposure rather than altered energy balance.	Ethanol	180-187	proopiomelanocortin	Rattus norvegicus	112-121	
18162070-11	2008	CONCLUSIONS: The present study shows that ethanol site specifically reduces alpha-MSH immunoreactivity in rat brain.	Ethanol	42-49	proopiomelanocortin	Rattus norvegicus	76-85