PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18073204-0	2008	The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail.	Tyrosine	4-12	S100 calcium binding protein B	Homo sapiens	89-92	
18073204-3	2008	In the case of the Nef-MHC-I complex, a tyrosine in the human leukocyte antigen (HLA)-A2 cytoplasmic tail ((320)YSQA) and a methionine in Nef (Met(20)) are absolutely required for AP-1 binding.	Tyrosine	40-48	S100 calcium binding protein B	Homo sapiens	19-22	
18073204-7	2008	The physiologically relevant tyrosine-dependent recruitment of AP-1 to MHC-I, which occurs whether Nef is present in cis or trans, was stabilized by the acidic and polyproline domains within Nef.	Tyrosine	29-37	S100 calcium binding protein B	Homo sapiens	99-102	
18073204-7	2008	The physiologically relevant tyrosine-dependent recruitment of AP-1 to MHC-I, which occurs whether Nef is present in cis or trans, was stabilized by the acidic and polyproline domains within Nef.	Tyrosine	29-37	S100 calcium binding protein B	Homo sapiens	191-194	
18073204-9	2008	Finally, mutation of the tyrosine binding pocket in the mu subunit of AP-1 created a dominant negative inhibitor of Nef-induced down-modulation of HLA-A2 that disrupted binding of wild type AP-1 to the Nef-MHC-I complex.	Tyrosine	25-33	S100 calcium binding protein B	Homo sapiens	116-119	
18073204-9	2008	Finally, mutation of the tyrosine binding pocket in the mu subunit of AP-1 created a dominant negative inhibitor of Nef-induced down-modulation of HLA-A2 that disrupted binding of wild type AP-1 to the Nef-MHC-I complex.	Tyrosine	25-33	S100 calcium binding protein B	Homo sapiens	202-205	
18073204-10	2008	Thus, these data provide evidence that Nef binding to the MHC-I cytoplasmic tail stabilizes the interaction of a tyrosine in the MHC-I cytoplasmic tail with the natural tyrosine binding pocket in AP-1.	Tyrosine	113-121	S100 calcium binding protein B	Homo sapiens	39-42	
18073204-10	2008	Thus, these data provide evidence that Nef binding to the MHC-I cytoplasmic tail stabilizes the interaction of a tyrosine in the MHC-I cytoplasmic tail with the natural tyrosine binding pocket in AP-1.	Tyrosine	169-177	S100 calcium binding protein B	Homo sapiens	39-42