PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17917407-5 2007 Confocal microscopy examination showed that in cultured rat cardiomyocytes, micrographic density of microtubules was increased by paclitaxel, a microtubule-polymerizing agent, and decreased by colchicine, a microtubule-depolymerizing agent, but not affected by ATII, isoproterenol, or tumor necrosis factor-alpha alone. Colchicine 193-203 angiotensinogen Rattus norvegicus 261-265 17917407-6 2007 Immunoblotting analysis showed that Bax/Bcl-2 ratio, which is associated with the activation of caspase-3, was significantly increased in ATII-stimulated cultured cardiomyocytes in vitro and in ATII-infused rats in vivo, both of which were inhibited by co-treatment with colchicine. Colchicine 271-281 angiotensinogen Rattus norvegicus 138-142 17917407-6 2007 Immunoblotting analysis showed that Bax/Bcl-2 ratio, which is associated with the activation of caspase-3, was significantly increased in ATII-stimulated cultured cardiomyocytes in vitro and in ATII-infused rats in vivo, both of which were inhibited by co-treatment with colchicine. Colchicine 271-281 angiotensinogen Rattus norvegicus 194-198 17917407-7 2007 Caspase-3 and TUNEL assay to detect apoptosis in vitro demonstrated that paclitaxel or ATII alone significantly enhanced and their combination further accelerated cardiomyocyte apoptosis, which was again significantly inhibited by colchicine. Colchicine 231-241 angiotensinogen Rattus norvegicus 87-91