PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17761346-2 2007 The importance of IL-2 down-regulation in preventing acute rejection in organ transplantation and the development of autoimmune diseases has been demonstrated by the therapeutic usefulness of the widely used immunosuppressants cyclosporine A and FK506. Cyclosporine 227-241 interleukin 2 Homo sapiens 18-22