PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17501721-8 2007 The pattern of NOX4-dependent ROS generation was unique: (i) ROS release upon NOX4 induction was spontaneous without need for a stimulus, and (ii) the type of ROS released from NOX4-expressing cells was H(2)O(2), whereas superoxide (O(2)(-)) was almost undetectable. Superoxides 221-231 NADPH oxidase 4 Homo sapiens 15-19 17501721-9 2007 Probes that allow detection of intracellular O(2)(-) generation yielded differential results: DHE (dihydroethidium) fluorescence and ACP (1-acetoxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine) ESR measurements did not detect any NOX4 signal, whereas a robust signal was observed with NBT. Superoxides 45-49 NADPH oxidase 4 Homo sapiens 226-230 17501721-10 2007 Thus NOX4 probably generates O(2)(-) within an intracellular compartment that is accessible to NBT (Nitro Blue Tetrazolium), but not to DHE or ACP. Superoxides 29-36 NADPH oxidase 4 Homo sapiens 5-9