PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17462533-0 2007 Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Reactive Oxygen Species 125-148 epidermal growth factor receptor Rattus norvegicus 45-77 17462533-10 2007 These results suggest that (1) IGF-I induces EGFR activation through production of ROS and ROS-mediated Src activation in VSMCs, and (2) EGFR transactivation is required for IGF-I-induced VSMC proliferation. Reactive Oxygen Species 83-86 epidermal growth factor receptor Rattus norvegicus 45-49 17462533-10 2007 These results suggest that (1) IGF-I induces EGFR activation through production of ROS and ROS-mediated Src activation in VSMCs, and (2) EGFR transactivation is required for IGF-I-induced VSMC proliferation. Reactive Oxygen Species 91-94 epidermal growth factor receptor Rattus norvegicus 45-49