PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17234795-0 2007 Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Azoxymethane 95-107 epidermal growth factor receptor Mus musculus 0-32 17234795-4 2007 In the current study, we used a specific EGFR antagonist, gefitinib, to investigate this role of the receptor in azoxymethane colonic premalignancy. Azoxymethane 113-125 epidermal growth factor receptor Mus musculus 41-45 17234795-10 2007 Azoxymethane significantly induced pro-transforming growth factor-alpha (6.4+/-1.3-fold) and increased phospho-(active) EGFR (5.9+/-1.1-fold), phospho-(active) ErbB2 (2.3+/-0.2-fold), and phospho-(active) extracellular signal-regulated kinase (3.3+/-0.4-fold) in premalignant colonocytes. Azoxymethane 0-12 epidermal growth factor receptor Mus musculus 120-124