PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17213183-0 2007 Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. Phospholipids 25-37 X-box binding protein 1 Homo sapiens 92-97 17213183-3 2007 We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the ER membrane, and enhanced activities of the choline cytidylyltransferase (CCT) and cholinephosphotransferase enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis. Phospholipids 154-166 X-box binding protein 1 Homo sapiens 26-31 17213183-8 2007 We propose that XBP-1(S) regulates ER abundance by coordinately increasing the supply of membrane phospholipids and ER proteins, the key ingredients for ER biogenesis. Phospholipids 98-111 X-box binding protein 1 Homo sapiens 16-21