PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17114179-0 2007 Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. plastochromanol 8 0-17 nuclear factor kappa B subunit 1 Homo sapiens 27-48 17114179-0 2007 Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. plastochromanol 8 0-17 mitogen-activated protein kinase kinase kinase 7 Homo sapiens 122-126 17114179-3 2007 Because the nuclear factor-kappaB (NF-kappaB) pathway has a central role in tumorigenesis, we investigated the effect of gamma-tocotrienol on the NF-kappaB pathway. plastochromanol 8 121-138 nuclear factor kappa B subunit 1 Homo sapiens 146-155 17114179-4 2007 Although gamma-tocotrienol completely abolished tumor necrosis factor alpha (TNF)-induced NF-kappaB activation, a similar dose of gamma-tocopherol had no effect. plastochromanol 8 9-26 tumor necrosis factor Homo sapiens 48-75 17114179-4 2007 Although gamma-tocotrienol completely abolished tumor necrosis factor alpha (TNF)-induced NF-kappaB activation, a similar dose of gamma-tocopherol had no effect. plastochromanol 8 9-26 tumor necrosis factor Homo sapiens 77-80 17114179-4 2007 Although gamma-tocotrienol completely abolished tumor necrosis factor alpha (TNF)-induced NF-kappaB activation, a similar dose of gamma-tocopherol had no effect. plastochromanol 8 9-26 nuclear factor kappa B subunit 1 Homo sapiens 90-99 17114179-5 2007 Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor. plastochromanol 8 13-30 nuclear factor kappa B subunit 1 Homo sapiens 46-55 17114179-5 2007 Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor. plastochromanol 8 13-30 interleukin 1 beta Homo sapiens 156-173 17114179-5 2007 Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor. Tetradecanoylphorbol Acetate 78-103 nuclear factor kappa B subunit 1 Homo sapiens 46-55 17114179-5 2007 Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor. Okadaic Acid 105-117 nuclear factor kappa B subunit 1 Homo sapiens 46-55 17114179-6 2007 Constitutive NF-kappaB activation expressed by certain tumor cells was also abrogated by gamma-tocotrienol. plastochromanol 8 89-106 nuclear factor kappa B subunit 1 Homo sapiens 13-22 17114179-8 2007 Mevalonate reversed the NF-kappaB inhibitory effect of gamma-tocotrienol, indicating the role of hydroxymethylglutaryl-CoA reductase. Mevalonic Acid 0-10 nuclear factor kappa B subunit 1 Homo sapiens 24-33 17114179-8 2007 Mevalonate reversed the NF-kappaB inhibitory effect of gamma-tocotrienol, indicating the role of hydroxymethylglutaryl-CoA reductase. plastochromanol 8 55-72 nuclear factor kappa B subunit 1 Homo sapiens 24-33 17114179-9 2007 Gamma-tocotrienol blocked TNF-induced phosphorylation and degradation of IkappaBalpha through the inhibition of IkappaBalpha kinase activation, thus leading to the suppression of the phosphorylation and nuclear translocation of p65. plastochromanol 8 0-17 tumor necrosis factor Homo sapiens 26-29 17114179-9 2007 Gamma-tocotrienol blocked TNF-induced phosphorylation and degradation of IkappaBalpha through the inhibition of IkappaBalpha kinase activation, thus leading to the suppression of the phosphorylation and nuclear translocation of p65. plastochromanol 8 0-17 NFKB inhibitor alpha Homo sapiens 73-85 17114179-9 2007 Gamma-tocotrienol blocked TNF-induced phosphorylation and degradation of IkappaBalpha through the inhibition of IkappaBalpha kinase activation, thus leading to the suppression of the phosphorylation and nuclear translocation of p65. plastochromanol 8 0-17 NFKB inhibitor alpha Homo sapiens 112-124 17114179-9 2007 Gamma-tocotrienol blocked TNF-induced phosphorylation and degradation of IkappaBalpha through the inhibition of IkappaBalpha kinase activation, thus leading to the suppression of the phosphorylation and nuclear translocation of p65. plastochromanol 8 0-17 RELA proto-oncogene, NF-kB subunit Homo sapiens 228-231 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 nuclear factor kappa B subunit 1 Homo sapiens 34-43 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 tumor necrosis factor Homo sapiens 93-96 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 TNF receptor superfamily member 1A Homo sapiens 98-103 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 TNFRSF1A associated via death domain Homo sapiens 105-110 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 TNF receptor associated factor 2 Homo sapiens 112-117 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 mitogen-activated protein kinase kinase kinase 7 Homo sapiens 119-123 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 mitogen-activated protein kinase kinase kinase 14 Homo sapiens 155-158 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 NFKB inhibitor alpha Homo sapiens 164-176 17114179-10 2007 gamma-Tocotrienol also suppressed NF-kappaB-dependent reporter gene transcription induced by TNF, TNFR1, TRADD, TRAF2, TAK1, receptor-interacting protein, NIK, and IkappaBalpha kinase but not that activated by p65. plastochromanol 8 0-17 RELA proto-oncogene, NF-kB subunit Homo sapiens 210-213 17114179-11 2007 Additionally, the expressions of NF-kappaB-regulated gene products associated with antiapoptosis (IAP1, IAP2, Bcl-xL, Bcl-2, cFLIP, XIAP, Bfl-1/A1, TRAF1, and Survivin), proliferation (cyclin D1, COX2, and c-Myc), invasion (MMP-9 and ICAM-1), and angiogenesis (vascular endothelial growth factor) were down-regulated by gamma-tocotrienol. plastochromanol 8 320-337 nuclear factor kappa B subunit 1 Homo sapiens 33-42 17114179-13 2007 Overall, our results demonstrate that gamma-tocotrienol inhibited the NF-kappaB activation pathway, leading to down-regulation of various gene products and potentiation of apoptosis. plastochromanol 8 38-55 nuclear factor kappa B subunit 1 Homo sapiens 70-79